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Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

Immunoinflammatory and Metabolic Responses in Post Cardiac Arrest Syndrome (PCAS)

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Aged 18 years or older
* Admitted to the intensive care unit after cardiac arrest episode
* Unresponsive after resuscitation

Exclusion Criteria:

* Moribund / actively dying at the time of evaluation
* Informed consent cannot be obtained within 24 hours of resuscitation
* Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion

About the study

This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

Sponsor: MaineHealth · Participants: 400 · Started: 2016-01

Contact the study team

• David B Seder, MD · Phone: 207-662-2179

Official record on ClinicalTrials.gov — NCT02664831

Locations in the U.S.

Conditions

• Sudden Cardiac Arrest
• Obesity
• Brain Hypoxia-Ischemia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.