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Vitamin D Dynamics in Women
Vitamin D Dynamics in Pregnant Women and Non-Pregnant Women of Reproductive Age
Who can join
Ages 20 to 39 · Women
Full eligibility criteria
Inclusion Criteria (Non-pregnant and pregnant participants participants): * Self-reported White and Black women * Age 20-39 * Body mass index (BMI) 1or pre-pregnancy BMI (If currently pregnant) either 18.5-24.9 kg/m2 or greater than or equal to 30 kg/m2 Inclusion Criteria (Additional criteria for pregnant participants): * Singleton pregnancy * Recruited in first trimester, second trimester, or third trimester * No pregnancy complications Exclusion Criteria (Non-pregnant and pregnant participants): * BMI or pre-pregnancy BMI \<18.5 kg/m2 * Human immunodeficiency virus (HIV) infection * Diagnosed eating disorder * Malabsorption disease * Diabetes * Elevated diastolic blood pressure (\>110 mm/Hg) * Steroid use * Substance abuse history * Current use of medications known to influence vitamin D or calcium homeostasis * Plans to travel to lower latitude during the 20-day study period * Plans to become pregnant during the study period (non-pregnant only) * Refuses to discontinue tanning bed use during study period * Refuses to discontinue vitamin or mineral supplement use during study period (non-pregnant only) Exclusion Criteria (Additional criteria for pregnant participants): * Gestational diabetes * Pregnancy hypertension
About the study
The goal of this project is to utilize stable isotopically labeled vitamin D3 and state of the art mass spectrometric methodology to assess vitamin D dynamics during pregnancy in relation to relation to obesity and vitamin D binding protein genotype. At the conclusion of this study, the investigators will have obtained novel information on the absorption and utilization of vitamin D in women and the degree to which vitamin D utilization during pregnancy is impacted by genetic ancestry, vitamin D binding protein concentration and genotype and by excess adiposity. The long-term goal is to better understand the unique metabolism of vitamin D during pregnancy.
What is being tested
- Vitamin D dynamics-pregnant (other)
- Vitamin D dynamics-nonpregnant (other)
Sponsor: Cornell University · Participants: 160 · Started: Oct 28, 2024
Contact the study team
- Kimberly O. O'Brien, PhD · Phone: 607-255-3743
Official record on ClinicalTrials.gov — NCT02705287
Locations in the U.S.
| New York | University of Rochester, 518 Hylan Building, Rochester |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.