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Prospective Research Rare Kidney Stones (ProRKS)

Who can join

All ages · All sexes

Inclusion Criteria:

1. Diagnosis of primary hyperoxaluria
2. Diagnosis of enteric hyperoxaluria
3. Diagnosis of Dent Disease
4. Diagnosis of Cystinuria
5. Diagnosis of adenine phosphoribosyltransferase deficiency (APRTd)
6. Diagnosis of Lowe Syndrome
7. Diagnosis of Dent Disease Carrier

Exclusion Criteria:

1. Prior renal failure
2. History of liver and/or kidney transplant.

About the study

The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.

Sponsor: Mayo Clinic · Participants: 220 · Started: 2016-05

Contact the study team

• Barb Seide · Phone: 800-270-4637
• Julie Olson, RN · Phone: 800-270-4637

Official record on ClinicalTrials.gov — NCT02780297

Locations in the U.S.

Conditions

• Hyperoxaluria
• Adenine phosphoribosyltransferase deficiency
• Primary Hyperoxaluria

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.