Home › Hypoglycemia › NCT02823665
The Effects of Bariatric Surgeries on Glucose Metabolism
RecruitingEarly phase 1Healthy volunteers welcome
Who can join
Ages 18 to 65 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl * Asymptomatic individuals with bariatric surgery * Healthy non-surgical patients with no personal history of diabetes * Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center Exclusion Criteria: * Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies; * RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea. * Healthy non-surgical patients with personal history of diabetes For administration of atropine, the following exclusions also apply: * History of glaucoma * Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia * Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study) * Myasthenia gravis * Brain pathology * Enlarged prostate in men
About the study
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
What is being tested
- Exendin-(9-39) (drug)
- Atropine (drug)
Sponsor: The University of Texas Health Science Center at San Antonio · Participants: 200 · Started: 2015-07
Contact the study team
- Marzieh Salehi, MD MS · Phone: 210-567-6691
- Jennifer Foster, MSN · Phone: 210-450-8696
Official record on ClinicalTrials.gov — NCT02823665
Locations in the U.S.
| Texas | South Texas Veterans Health Care System, San Antonio Texas Diabetes Institute - University Health System, San Antonio |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.