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Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study Evaluating the Impact of Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions
Who can join
Ages 18 to 84 · All sexes
Full eligibility criteria
Inclusion Criteria: * Adult patient undergoing endoscopic surgery for resection of pituitary tumors for nonfunctioning adenoma, acromegaly, or prolactinoma * Adults \>18 and \<85 years of age * English speaking and able to understand the ASK Nasal-12 and SNOT-22 scales * Free of any physical, mental, or medical condition which, in the opinion of the investigator, makes study participation inadvisable Exclusion Criteria: * Anaphylaxis/intolerance to the study drugs * Cirrhosis, hepatitis * Any solid organ transplant or bone marrow transplant. And any patient felt to be immunocompromised by the investigators * Renal failure on dialysis * Any subject who is unwilling or unable to sign informed consent for the study * Pregnancy * Incarcerated patients * Cushing's disease * Rathke's Cleft cyst or pituitary cyst * History of chronic sinusitis * Anticipated use of nasal splints * Anticipated use of nasal septal flap * Active sinusitis * Nasal polyps * Previous sinus surgery * Concurrent antibiotics for another indication (i.e., urinary tract infection) * Immunodeficiency
About the study
To find out whether oral antibiotics given after transsphenoidal endoscopic surgery for pituitary adenoma improves sinus and nasal symptoms, reduces the incidence of infection (sinusitis), and helps mucosal healing in the nasal passages.
What is being tested
- Placebo (drug)
- Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole (drug)
Sponsor: St. Joseph's Hospital and Medical Center, Phoenix · Participants: 116 · Started: Jul 1, 2017
Contact the study team
- Heidi Jahnke, RN, MSN · Phone: 602-406-6976
Official record on ClinicalTrials.gov — NCT03014687
Locations in the U.S.
| Arizona | Barrow Brain and Spine, Phoenix |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.