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Patient-Centered NeuroRehabilitation (PCN)

Patient-Centered NeuroRehabilitation

Who can join

Ages 50 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Individuals who have reported cognitive dysfunction and cognitively intact participants.
2. Participants will be age 50 or older

Exclusion Criteria:

1. A history of epilepsy
2. Sensory or motor impairments that limit the ability to take part in the study
3. Current alcohol or drug abuse/dependence
4. Those who are currently pregnant or may become pregnant during the duration of the study (if there is a question of pregnancy, pregnancy tests will be available for participants at no charge)

Those who are being evaluated for TES methodology will also be excluded for 1) metallic or electronic implant 2) skull plates or other cranial implants that affect TES

About the study

As individuals grow older, a number of factors can reduce our cognitive (or thinking) abilities such as "normal" aging, neurodegenerative diseases, and cardiovascular disease. This study will evaluate whether cognitive rehabilitation and transcranial electrical stimulation (TES) can improve cognitive abilities. Cognitive rehabilitation refers to methods that are used to improve tasks people have trouble doing in everyday life. Transcranial electrical stimulation uses small amounts of electricity to try to alter brain functioning. These approaches may help improve cognitive abilities like attention, learning, memory, finding words, and problem solving as well as everyday functioning. The goal of this study is to identify how to best use these methods, either alone or in combination.

What is being tested

• Active tDCS (device)
• Sham tDCS (device)
• Cognitively based intervention (behavioral)
• Active tACS (device)
• Sham tACS (device)
• Active tRNS (device)

Sponsor: University of Michigan · Participants: 500 · Started: 2016-06

Contact the study team

• Kayla Rinna, M.S. · Phone: 734-936-7739
• Eileen Robinson, RN, MPH · Phone: 734-763-1356

Official record on ClinicalTrials.gov — NCT03036319

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.