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Genetic Basis of Melanocytic Nevi
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion criteria: * Male or female subjects that are 18 years or older * Subjects with melanocytic nevi\\ Exclusion criteria: * Patients less than 18 years of age * Patients without melanocytic nevi * Patients with a bleeding disorder or are taking anticoagulation medication
About the study
The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.
Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:
1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
What is being tested
- Collecting Nevi (other)
Sponsor: University of California, Davis · Participants: 50 · Started: Jun 26, 2017
Contact the study team
- Maija Kiuru, MD · Phone: 916-734-0591
- John Robb · Phone: 916-551-2636
Official record on ClinicalTrials.gov — NCT03054584
Locations in the U.S.
| California | University of California-Davis, Department of Dermatology, Sacramento |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.