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Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

Who can join

1 Day · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* The Engle Lab is very interested in enrolling individuals with congenital conditions related to eye movement, cranial nerve and brainstem-based dysfunction, often broadly referred to as congenital cranial dysinnervation disorders (CCDDs).

Exclusion Criteria:

* Individuals with cranial nerve disorders associated with known disorders, such as Saethre-Chotzen associated with established genetic mutations, or acquired conditions including trauma, stroke, tumor or spinal cord injuries.

About the study

The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.

Sponsor: Boston Children's Hospital · Participants: 20,000 · Started: Feb 1, 2004

Contact the study team

• Brenda J Barry, MS · Phone: 617-919-2168
• Engle Admin · Phone: 617-919-4030

Official record on ClinicalTrials.gov — NCT03059420

Locations in the U.S.

Conditions

• Eye Movement Disorders
• Strabismus

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.