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Bronchial NIR Image-guided Resection

Bronchial NIR Image-guided Resection, Mapping And Targeted Lymphadenectomy for Lung Lesions

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients that have agreed to undergo video assisted thoracoscopic surgery or thoracotomy for surgical resection as recommended by their thoracic surgeon.
* 18 years of age or older
* Documented, signed, dated informed consent obtained prior to any study specific procedures being performed

Exclusion Criteria:

* Pregnant women are excluded and women of childbearing potential without a negative pregnancy test prior to study procedures. All patients with Iodine allergies will be excluded.

About the study

This is a clinical trial to evaluate the use of peritumoral injection of near-infrared dye indocyanine green to identify lung lesions and sentinel lymph nodes. The primary purpose is to determine if the use of ICG injected via navigational bronchoscopy, CT-guided or transthoracic allows us to identify the first lymph node that drains from the tumor, and thus would be the most likely site for metastatic disease, and remove it for analysis to improve the ability to detect tumor in this node and to remove this additional site that potentially contains tumor cells. Using this intraoperative imaging technique, we aim to improve the identification of lung nodules for resection and the intraoperative identification of sentinel lymph nodes in the event that a lymphadenectomy is performed.

What is being tested

• ICG Intervention (drug)
• Near Infrared Imaging (device)

Sponsor: Massachusetts General Hospital · Participants: 100 · Started: Jan 6, 2015

Contact the study team

• Yolonda Colson, MD, PhD · Phone: 617-726-5200
• Isha Mehta Warikoo, MD · Phone: 18572501355

Official record on ClinicalTrials.gov — NCT03097575

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.