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Study of Food Aversion in Patients With Anorexia Nervosa

RecruitingHealthy volunteers welcome

Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa

Who can join

Ages 18 to 55 · Women · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Ill AN subjects will meet current Diagnostic and Statistical Manual of Mental Disorders (DSM V) diagnosis of AN, body mass index (BMI) between 11 kg/m² and 17.5 kg/m², or BMI \> 17.5 kg/m² with active eating disorder symptoms.
* Recovered AN must meet the following criteria at time of study entry: 1) Current or past DSM V diagnosis of AN; 2) BMI between 18.5 kg/m2 and 30 kg/m2; 3) Having maintained a BMI of \>18.5 for at least one year.
* Control must be healthy adolescent or woman negative on our screen for AN, other Axis I psychiatric illnesses, and having maintained a BMI of between 18.5-30 kg/m² since the age of 18.

Exclusion Criteria:

* Exclusion criteria for AN and control subjects include: Organic brain syndrome, schizophrenia and schizoaffective disorder, untreated thyroid disease, renal disease, hepatic disease, and the regular use of fish-oil containing supplements within the last three months of the study. All pregnant and lactating individuals will be excluded.

About the study

This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.

What is being tested

Sponsor: University of California, San Diego · Participants: 300 · Started: Nov 10, 2016

Contact the study team

Official record on ClinicalTrials.gov — NCT03100656

Locations in the U.S.

CaliforniaUC San Diego Altman Clinical and Translational Research Institute, La Jolla

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.