Interventions for Postoperative Delirium: Biomarker-3
RecruitingObservational studyHealthy volunteers welcome
Who can join
Ages 60 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Cohort 1: Age ≥65 years * Cohort 2: Age ≥60 years * Anticipated length of hospital stay of at least 2 days after surgery that occurs under general or neuraxial anesthesia * Written Informed Consent for potential participation prior to surgery Exclusion Criteria: * Contraindication to EEG * Unable or unwilling to attend the follow-up appointments * Documented history of dementia * Deemed incapable of providing consent by surgical team * Residing in a nursing home * Undergoing intracranial surgery * Unable to complete neurocognitive testing due to language, vision or hearing impairment * Unable to communicate with the research staff due to language barriers * For optional MRI portion of the study: Contraindication to MRI (e.g., implanted devices not safe for MRI studies, claustrophobia, unable to lie flat or still)
About the study
The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.
What is being tested
- High Density-Electroencephalogram (procedure)
- Magnetic Resonance Imaging (procedure)
- Blood specimen collection (procedure)
- Pupillometry (diagnostic test)
Sponsor: University of Wisconsin, Madison · Participants: 468 · Started: Feb 13, 2017
Contact the study team
- David Kunkel, BS · Phone: 608-262-6469
- Frankie Ingram, BS · Phone: 608-262-6469
Official record on ClinicalTrials.gov — NCT03124303
Locations in the U.S.
| Wisconsin | University of Wisconsin-Madison, Madison |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.