Improving Measurement and Treatment of Post-stroke Neglect
Recruiting
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Ischemic or hemorrhagic stroke 3 months post stroke * Fugl-Meyer Upper Extremity (FMA-Upper Extremity) score between 20-56/60 * Inducible motor evoked potential (MEP) of the abductor pollicis brevis (APB) on the paretic stimulation (TMS) * Demonstrate the presence of unilateral neglect (Virtual Reality Lateralized Attention Test score \<18) Exclusion Criteria: * History of cortical hemorrhagic stroke * Presence of any MRI, TMS, tDCS risk factors including: * history of seizures * history of brain tumor * hardware in skull or spine (e.g. coils, clips) * implantable medical device (e.g. pacemaker) * metal in body (not compatible with MRI) * pregnancy * Severe spasticity (Modified Ashworth Scale score 3) * Severe aphasia or cognitive impairment limiting participants' comprehension (National Institutes of Health Stroke Scale Level of Consciousness Commands Item score 1 or Best Language Item score 2) * Unable to travel to UE Motor Function Laboratory at the Center for Rehabilitation Research in Neurological Conditions (a collaborative, Memorandum of Understanding (MOU) approved, research center Ralph H. Johnson VA Medical Center and the Medical University of South Carolina) for the study
About the study
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.
What is being tested
- Sham transcranial direct current stimulation (tDCS) (device)
- Active direct current stimulation (tDCS) (device)
Sponsor: VA Office of Research and Development · Participants: 17 · Started: Jul 2, 2018
Contact the study team
- Emily S Grattan, PhD MS BS · Phone: (412) 559-4920
Official record on ClinicalTrials.gov — NCT03317860
Locations in the U.S.
| Pennsylvania | VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.