Home › Carotid Artery Disease › NCT03344276
Assessing Neurocognition After Cerebrovascular Intervention
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * patients \>18 years of age * ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis. Exclusion Criteria: 1. patients \<18 years of age 2. patients with without compatibility for MRI 3. patients requiring carotid stenting for reasons not related to long-standing stenosis 4. patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure. 5. Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.
About the study
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.
What is being tested
- Neurocognitive Assessments (diagnostic test)
- Measurements of inflammatory biomarkers (diagnostic test)
- Carotid Artery Stenting (procedure)
Sponsor: University of California, San Diego · Participants: 20 · Started: Jul 15, 2021
Contact the study team
- Alexander Khalessi, MD · Phone: (619) 543-5540
- ARVIN WALI, BA, MAS · Phone: 7149282722
Official record on ClinicalTrials.gov — NCT03344276
Locations in the U.S.
| California | UCSD Medical Center, San Diego |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.