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In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells in Healthy Subjects Using Stable Isotope Resolved Metabolomics: A Pilot Study

Who can join

Ages 18 to 60 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Ages 18-60
* Able to provide written consent

Exclusion Criteria:

* Renal Failure
* Pregnancy
* Active steroid use
* Active liver Disease
* Anemia (Hemoglobin \< 12.5 g/dL in men and \< 11.5 g/dL in women)
* H/O alcohol use (average \> 2 drinks per day)
* BMI \> 30

About the study

This pilot study will first establish the feasibility of an in vivo methodology of assessing the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from healthy subjects while comparing it to an ex vivo approach

What is being tested

• 5-13C-Glutamine (other)
• Bone marrow aspiration (other)

Sponsor: Mayo Clinic · Participants: 20 · Started: Sep 1, 2017

Contact the study team

• Wilson Gonsalves · Phone: 5072842511

Official record on ClinicalTrials.gov — NCT03384108

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.