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The Venous Distension Reflex and Orthostatic Hypertension
RecruitingHealthy volunteers welcome
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Are capable of giving informed consent * Are of any race or ethnicity * Are fluent in written and spoken English * Whose history and physical exam did not uncover any exclusion criteria * Are 18 years of age For subjects with elevated standing BP * Systolic BP (SBP) during standing is at least 10 mmHg \> the supine SBP * Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED For normal subjects without elevated standing BP * The change in SBP by standing is within ± 5 mmHg from the supine SBP * Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP * Free of acute or chronic medical conditions Exclusion Criteria: * Age \< 18 years of age * Are a pregnant or nursing woman * Are a prisoner or institutionalized individual or unable to consent * Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension * Have orthostatic hypotension or a history of syncope * Current smoker * History of blood clots
About the study
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
What is being tested
- Tilt + external pressure (other)
- Tilt + no external pressure. (other)
- Limb occlusion + negative pressure (other)
- Limb occlusion + no negative pressure (other)
Sponsor: Milton S. Hershey Medical Center · Participants: 30 · Started: Mar 10, 2020
Contact the study team
- Jian Cui, PhD · Phone: 717-531-1799
- Kris Gray · Phone: 717-531-4589
Official record on ClinicalTrials.gov — NCT03496792
Locations in the U.S.
| Pennsylvania | Penn State Milton S. Hershey Medical Center, Hershey |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.