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DNA Methylation and Vascular Function
RecruitingHealthy volunteers welcome
DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight Loss
Who can join
Ages 18 to 50 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * BMI ≥ 35 kg/m2 * Between ages 18-50 years * Not pregnant * Approved for a bariatric surgery Exclusion Criteria: * To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded * Pregnant women will be excluded, as they will not be eligible for bariatric surgery * Current smokers * Currently abusing alcohol or drugs
About the study
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.
What is being tested
- Exercise training (other)
Sponsor: University of Illinois at Chicago · Participants: 80 · Started: Oct 11, 2019
Contact the study team
- Abeer Mohamed, MD, PhD · Phone: 3127539998
Official record on ClinicalTrials.gov — NCT03527420
Locations in the U.S.
| Illinois | University of Illinois at Chicago, Chicago |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.