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Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules

Retrospective-Prospective Collection of Thyroid Specimens After FNA

Who can join

Ages 19 and older · All sexes

Inclusion Criteria:

* All patients undergoing FNA for thyroid nodule diagnosis.
* Any race and ethnicity are eligible for the study.
* Patient should have thyroid nodule(s) with indeterminate diagnosis after FNA (Bethesda category of indeterminate FNA \[III-V\]).

About the study

This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules. Using diagnostic testing, such as the diagnostic DNA methylation signature, may be a less invasive way to check for thyroid cancer.

What is being tested

• Diagnostic DNA Methylation Signature (other)

Sponsor: City of Hope Medical Center · Participants: 22 · Started: Jan 1, 2027

Contact the study team

Official record on ClinicalTrials.gov — NCT03676647

Locations in the U.S.

Conditions

• Thyroid Nodule

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.