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Developing Viability Index for Machine Perfused Livers
Development of a Liver Viability Index for Transplantation
Who can join
Ages 18 to 75 · All sexes
Full eligibility criteria
Inclusion Criteria: * Male or female 18-75 years of age. * Candidate for a deceased-donor liver allograft. Exclusion Criteria: * Seropositivity for HIV-1.
About the study
Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable. However, there are no validated metrics to determine transplantability after machine perfusion. This study involves collecting biopsies from transplanted livers before and after implantation to correlate metabolite and gene expression with post-transplant function. This data will help develop a viability index for machine perfused livers.
What is being tested
- Liver Biopsy (diagnostic test)
Sponsor: Massachusetts General Hospital · Participants: 60 · Started: Oct 1, 2018
Contact the study team
- Heidi Yeh, MD · Phone: 617-726-3664
Official record on ClinicalTrials.gov — NCT03694691
Locations in the U.S.
| Massachusetts | Massachusetts General Hospital, Boston |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.