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Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: a Dimensional Approach
Who can join
Ages 18 to 80 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Must be between 18-80 years old * Males or females * Must be right handed * Must be able to sit unaccompanied for long periods of time with little body movement * Must be illicit drug free at time of scanning as appropriate (UDS negative), * Must be either healthy (without medical, neurological, psychiatric illness) or have a diagnosis of a neuropsychiatric syndrome (mood disorder, chronic pain syndrome, dementias, traumatic brain injury, substance/alcohol use disorder). * Healthy Control volunteers must be medication free (≥ 14 days) * Illicit drug free at time of scanning (verified by negative urine drug screen) Exclusion Criteria: * Must not be a smoker. * Females must not be pregnant or nursing. * Must not suffer from claustrophobia * Must not meet exclusion criteria for MRI scanning (i.e. non-fixed magnetisable objects) * Must not be PBR-28 low affinity binder (or using the \[11C\]ER176 study radiotracer) * Healthy control volunteers must not have on-going, chronic, or relapsing/remitting medical, psychiatric (absence of both DSM-IV Axis I and/or Axis II disorders), or neurological illness as determined by combination of history, medical record, and/or examination.
About the study
The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer \[11C\]PBR-28 or \[11C\]ER176.
What is being tested
- PET with radiotracer [11C]PBR-28 ( or [11C]ER176) (drug)
- Affective challenge (other)
Sponsor: The University of Texas Health Science Center, Houston · Participants: 200 · Started: May 1, 2017
Contact the study team
- Alan Prossin, MBBS · Phone: 713-486-2836
Official record on ClinicalTrials.gov — NCT03705715
Locations in the U.S.
| Texas | BBSB at UTHealth, Houston |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.