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Genetic and Epigenetic Basis of Chronic Wounds

Who can join

Ages 18 to 100 · All sexes

Inclusion Criteria:

* Age ≥ 18 years
* Willing to comply with protocol instructions, including all study visits and study activities.
* Chronic wounds (\> than four weeks since onset)
* Clinically diagnosed diabetic or non-diabetic ulcer.
* For patients with multiple wounds, the largest wound will be used for the study.

Exclusion Criteria:

* Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)
* Pregnant females (self-declared) or lactating
* Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications)
* Prisoners

About the study

This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.

What is being tested

• No Interventions (other)

Sponsor: University of Pittsburgh · Participants: 256 · Started: Dec 4, 2018

Contact the study team

• Piya Das Ghatak, PhD, MS · Phone: 412-648-8297
• Sashwati Roy, PhD · Phone: 412-648-8297

Official record on ClinicalTrials.gov — NCT03793062

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.