Home › Preeclampsia › NCT03806283
Mechanisms of Pregnancy Vascular Adaptations
Angiotensin 2 Receptor (AT2R) Expression/Activation in Endothelial Cells in Preeclampsia
Who can join
Ages 18 to 40 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Female * Ages 18 to 40 years old * Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent * Undergoing caesarean section, either planned or otherwise with or without trial of labor Exclusion Criteria: * Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia. * Any major fetal structural anomalies or aneuploidies * Undergoing cesarean section for placental abruption or bleeding complications. * Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)
About the study
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.
What is being tested
- Omental Biopsy (procedure)
Sponsor: University of Wisconsin, Madison · Participants: 166 · Started: Nov 20, 2018
Contact the study team
- UW Ob/Gyn Human Subjects Core · Phone: 608-890-3345
Official record on ClinicalTrials.gov — NCT03806283
Locations in the U.S.
| Wisconsin | UnityPoint Health-Meriter Hospital, Madison |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.