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Pencil Beam Scanning in Patients With Renal Tumors

Pilot Study of Pencil Beam Scanning Proton Beam Radiation Therapy in Patients With Renal Tumors

Who can join

Ages 0 to 30 · All sexes

Inclusion Criteria:

* Less than 30 years of age
* Diagnosis

  a. Any patient with Wilms tumor or clear cell sarcoma of the kidney who would require radiation therapy as standard of care including
  1. Any patient with favorable histology (FH), stage III disease
  2. Any patient with focal or diffuse anaplasia
  3. Any patient with CCSK
* The patient is a candidate for external beam radiotherapy based on standard of care for treatment of Wilms tumor or CCSK

Exclusion Criteria:

* Prior radiotherapy to the region of the study cancer
* Chemotherapy administered for diagnosis of Wilms tumor or CCSK
* Pregnant or breastfeeding

About the study

This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.

What is being tested

• Proton beam radiation using pencil beam scanning (other)

Sponsor: Children's Hospital of Philadelphia · Participants: 28 · Started: Dec 26, 2017

Contact the study team

• Christine Hill-Kayser, MD · Phone: 215-590-2810

Official record on ClinicalTrials.gov — NCT03810651

Locations in the U.S.

Conditions

• Kidney Cancer (Renal Cell Carcinoma)
• Wilms Tumor

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.