Home › Chronic Subdural Hematoma › NCT03831997
Effect of Different Intravenous Fluids on Post-operative Chronic Subdural Hematoma Size and Recurrence
The Effect of Dextrose 5% in 0.225% Sodium Chloride (D5 1/4NS) on Postoperative Chronic Subdural Hematoma Size and Recurrence Rate
Who can join
Ages 18 to 65 · All sexes
Full eligibility criteria
Inclusion Criteria: * Diagnosis of chronic subdural hematoma (based on imaging) * Need for surgical intervention (assessed by attending neurosurgeon based on full neurological assessment) * The procedure of choice is burr hole drainage * Cessation of anti-coagulant therapy with accompanying normal lab values in appropriate time frames respective to the drug * Tolerance of supine position Exclusion Criteria: * \<60 years old * Presence of acute hemorrhage, stroke, or parenchymal damage * Neurological deficits not accountable to mass effect * Hyponatremia or inherent electrolyte imbalances * Pregnancy or non-consentable patients * Previous neurological surgery up to 1 year before being considered for the study * Rapid re-expansion of brain observed intraoperatively by attending neurosurgeon * Congestive heart failure or other medical conditions precluding normal postoperative administration of IV fluids * Blood glucose levels \> 135 mg/dL
About the study
This study aims to reduce the recurrence rate of chronic subdural hematomas (CSDH) by manipulating the post-operative intravenous fluid use. The hypothesis relies on the relationship between osmolality and volume changes related to osmolality. We will be administering dextrose 5% in 1/4 normal saline (D5 1/4NS) post-operatively to induce brain expansion which can take up the residual CSDH space, to help reduce recurrence rate.
What is being tested
- Dextrose 5% W/ Sodium Chloride 0.225% (drug)
Sponsor: Carilion Clinic · Participants: 35 · Started: Jan 17, 2019
Contact the study team
- Eric A Marvin, DO · Phone: 5405889711
- Ayesha Kar, BS · Phone: 9082080082
Official record on ClinicalTrials.gov — NCT03831997
Locations in the U.S.
| Virginia | Carilion Roanoke Memorial Hospital, Roanoke |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.