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Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

Molecular Detection of Advanced Neoplasia in Pancreatic Cysts (IN-CYST)

Who can join

Ages 18 to 120 · All sexes

Inclusion Criteria:

* Patients with pancreatic cystic lesions meeting Fukuoka worrisome or Fukuoka high-risk criteris
* Patients with suspected cystic neoplasm of the pancreas
* Able to provide written informed consent

Exclusion Criteria:

* Pregnant and/or nursing
* Incarceration
* Imaging showing possible pancreatic cancer
* Prior history of pancreatic cancer or pancreatic surgery
* History of receiving systemic chemotherapy or abdominal radiation within the last 5 years
* Previous therapy for a pancreatic cystic lesion
* History of pancreatic necrosis
* Diagnosis of cancer (other than non-melanoma skin cancer) within the last 5 years

About the study

Researchers are trying to find out whether new tests ("biomarkers") of blood, stool, pancreas cyst fluid, or pancreas juice can be used to diagnose malignant or pre-malignant changes in pancreas cysts.

What is being tested

• Blood, stool, pancreatic juice and cyst fluid collection (diagnostic test)
• Pancreatic Surgery (procedure)
• Endoscopy Exam (procedure)

Sponsor: Mayo Clinic · Participants: 800 · Started: May 11, 2018

Contact the study team

• IN-CYST Team · Phone: 1-833-250-5364

Official record on ClinicalTrials.gov — NCT03855800

Locations in the U.S.

Conditions

• Pancreatic Cyst

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.