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Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment

Assessment of Intra-Operative Atrial Fibrillation Inducibility As a Screening Tool to Prevent Post-Operative Atrial Fibrillation With Prophylaxis Amiodarone

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Patients scheduled for first-time non-emergent open-heart surgery for coronary artery bypass graft (CABG) revascularization, valvular repair or replacement, combined CABG with valve repair or replacement, or valve sparing aortic root repair
* Normal sinus rhythm
* No documented history of atrial fibrillation

Exclusion Criteria:

* Prior surgical procedures involving heart surgery and cardiopulmonary bypass
* Any prior documented history of atrial fibrillation, atrial flutter or atrial tachycardia lasting longer than 30 seconds
* Prior history of Amiodarone treatment for the management of supraventricular tachy-arrhythmias
* Patients requiring surgical treatment of atrial arrhythmias such as pulmonary vein isolation or Maze procedure.

About the study

Patients undergoing first time cardiac surgery will undergo rapid atrial pacing prior to initiation of cardiopulmonary bypass to screen for AF inducibility. Patients with inducible AF will be randomized to prophylactic amiodarone treatment versus no treatment. Patients who are not inducible to AF will be treated with standard post-operative care. Patients will be monitored post-operatively to explore the value of intraoperative inducibility of AF to predict POAF and to evaluate whether the combination of intraoperative inducibility and precision amiodarone therapy is effective at reducing the incidence of POAF

What is being tested

• Amiodarone Injection (drug)
• Intraoperative Rapid Atrial Pacing (device)

Sponsor: Stanford University · Participants: 600 · Started: Mar 1, 2017

Contact the study team

• Anson Lee, MD · Phone: 650-724-7500

Official record on ClinicalTrials.gov — NCT03868150

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.