Home › Weight Loss Surgery › NCT03868592

Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Who can join

Ages 18 to 65 · All sexes

Inclusion Criteria:

* BMI 40 - 50 kg/m2.
* Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery

Exclusion Criteria:

* Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
* Active coronary artery disease
* Participation in structured exercise (\>2 times per week for 30 minutes or longer)
* Smoking
* Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)
* Renal insufficiency (serum creatinine \> 1.5mg/dl)
* Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L)
* Pregnancy or breastfeeding.

About the study

It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.

What is being tested

• Gastric sleeve/bariatric surgery (procedure)

Sponsor: Mayo Clinic · Participants: 30 · Started: Aug 1, 2019

Contact the study team

Official record on ClinicalTrials.gov — NCT03868592

Locations in the U.S.

Conditions

• Weight Loss Surgery

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.