Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
Recruiting
A Phase III Randomized Trial Comparing the Effects of Volume Support and Assist Control Mode Ventilation on Ventilator-Free Days and Diaphragmatic Atrophy
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: subjects \> 18 years of age that have been intubated and mechanically ventilated for \< 36 hours at the time of screening will be eligible for enrollment Exclusion Criteria: 1. pregnancy 2. cardiopulmonary arrest 3. history of diaphragmatic paralysis or neuromuscular disease 4. chronic obstructive pulmonary disease (COPD) or asthma exacerbation with evidence of auto-PEEPing requiring intubation 5. neuromuscular blockade 6. expectation to be liberated from ventilator in \< 24 hours 7. history of mechanical ventilation in the last 6 months 8. presence of tracheostomy 9. high cervical spine injury
About the study
The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.
What is being tested
- Volume Support Mode Mechanical Ventilation (other)
- Assist Control Mode Mechanical Ventilation (other)
Sponsor: University of Chicago · Participants: 468 · Started: Mar 4, 2019
Contact the study team
- Bhakti Patel, MD · Phone: 773-702-0902
- Anne S Pohlman, MSN · Phone: 773-702-3804
Official record on ClinicalTrials.gov — NCT03901924
Locations in the U.S.
| Illinois | The University of Chicago Medical Center, Chicago |
| Iowa | University of Iowa, Iowa City (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.