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Gene Expression Changes In Young and Geriatric Skin
Gene Expression Changes in Young and Geriatric Skin
Who can join
Ages 21 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Male/Female * White skin (Fitzpatrick types I and II) * Age 21-30 or 65 and older * Able to comprehend procedures/risks Exclusion Criteria: * Known photosensitivity * Currently on photosensitizing medications * Diabetes Mellitus * History of abnormal scarring * History of skin infections * Known allergy to lidocaine local anesthetic * Pregnancy or nursing * Other serious health issues
About the study
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
What is being tested
- Insulin-Like Growth Factor 1 (drug)
- No Insulin-Lie Growth Factor 1 (other)
Sponsor: Wright State University · Participants: 24 · Started: Sep 6, 2019
Contact the study team
- Manager, Clinical Research Operations · Phone: 937-245-7500
- Regulatory Specialist · Phone: 937-245-7500
Official record on ClinicalTrials.gov — NCT03932162
Locations in the U.S.
| Ohio | Wright State Physicians, Fairborn |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.