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Pulmonary Hemodynamics During Exercise - Research Network

RecruitingObservational study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
* Written informed consent of participating subjects after being fully briefed (for prospective analysis)

Exclusion Criteria:

* Patients with incomplete hemodynamic data at rest or exercise
* Patients without sufficient follow-up data (information on survival / lung transplantation)
* advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
* advanced heart failure with pulmonary arterial wedge pressure (PAWP) \> 18 mmHg at rest
* uncontrolled systemic arterial hypertension (RR values \> 160/100 mmHg at rest)
* FEV1\<50% predicted
* TLC\<60% predicted

About the study

The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.

What is being tested

assessment of pulmonary hemodynamics during exercise by right heart catheterization (diagnostic test)

Sponsor: Medical University of Graz · Participants: 1,500 · Started: Dec 1, 2018

Contact the study team

Gabor Kovacs, MD · Phone: +43-316-385

Official record on ClinicalTrials.gov — NCT03954574

Locations in the U.S.

Arizona	University of Arizona, Banner University Medical Center, Phoenix
California	University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine, Los Angeles
Maryland	Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA, Baltimore
Massachusetts	Harvard Medical School, Brigham and Women's Hospital, Boston Massachusetts General Hospital, Cardiology Division and Pulmonary Unit, Boston
Minnesota	University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA, Minneapolis Mayo Clinic, Division of Cardiovascular Diseases, Department of Medicine, Rochester
South Carolina	Medical University of South Carolina, Charleston

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.