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The Validity of the Quick Renal MRI in Pediatric Kidney Disease

Who can join

Ages 0 to 21 · All sexes

Inclusion Criteria:

* Aim 1:

  * Patient is admitted to American Family Children's Hospital for a febrile UTI, suspected pyelonephritis, or diagnosed pyelonephritis
  * Undergoing clinical DMSA scan
* Aim 2:

  * Undergoing DMSA scans as a part of their routine clinical care
  * History of more than one UTI in the past year

Exclusion Criteria:

* Aim 1:

  * No evidence of pyuria on their urine analysis
  * Negative urine culture
  * Not comfortable with having a Quick MRI performed
* Both aims:

  * Contraindications to MRI

About the study

The investigators propose a new imaging method for children born with congenital anomalies of the urinary tract that is a rapid, injection-, sedation-, and radiation-free alternative: the quick renal MRI. This proposal hypothesizes that the quick renal MRI has high validity compared to current radiologic standard for renal infection and scarring, the 99mTechnetium-dimercaptosuccinic acid (99mTc- DMSA) renal scan in the detection of acute renal infections and scars. If the quick renal MRI is accurate, it could potentially replace the DMSA scan for those specific questions and ease the burden of testing for children with chronic renal disease. Findings from these studies will provide preliminary data and rationale for a multi-centered study to further test this new technology.

Participants will be 0-21 years of age and can expect to be on study for from 1 week (if enrolled in Aim 1) to 6 months (if enrolled in Aim 2).

What is being tested

• Quick MRI (diagnostic test)

Sponsor: University of Wisconsin, Madison · Participants: 100 · Started: May 7, 2019

Contact the study team

• Shannon Cannon, MD · Phone: (608) 265-8574

Official record on ClinicalTrials.gov — NCT03959163

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.