Home › Essential Tremor › NCT03984643
Algorithms for Programming DBS Systems for ET
Who can join
Ages 21 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * diagnosis of ET * medication-refractory tremor * VIM-DBS implant (unilateral or bilateral) * 7T MRI pre-operative scan under Dr. Harel's IRB (institutional review board) protocol (#1210M22183) * Post-operative CT scan Exclusion Criteria: * history of musculoskeletal disorders that affect movement of the limbs * other significant neurological disorder * prior history of stereotactic neurosurgery (other than VIM-DBS surgery) * pregnancy
About the study
Deep brain stimulation (DBS) targeting the Vim thalamus (ventralis intermedius nucleus) is an FDA-approved neuromodulation therapy for treating postural and action tremor in individuals with essential tremor (ET). The success of this treatment, however, is highly dependent on the ability of clinicians to identify therapeutic stimulation settings through a laborious programming process. There is a strong and growing clinical need for new approaches to provide clinicians with more efficient guidance on how to titrate stimulation settings. This study will leverage subject-specific computational models that can predict neural activation of axonal pathways adjacent to the active electrode(s) and implicated in the therapeutic mechanisms of Vim-DBS to in turn guide clinicians with which stimulation settings are likely to be the most therapeutic on tremor.
What is being tested
- Vim-Deep Brain Stimulation (device)
Sponsor: University of Minnesota · Participants: 25 · Started: Oct 1, 2019
Contact the study team
- Matthew Johnson, PhD · Phone: 6126266492
Official record on ClinicalTrials.gov — NCT03984643
Locations in the U.S.
| Minnesota | University of Minnesota, Minneapolis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.