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Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

Who can join

Ages 22 to 33 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Singleton birth
* Born at less than 34 weeks gestational age (preterm cohort)
* Born at greater than 36 weeks gestational age (term cohort)

Exclusion Criteria:

* Twin birth
* Congenital anomalies or genetic syndromes
* Currently pregnant or breast feeding
* Subject-reported history of hypertension
* Current use of antihypertensive medications
* Active cancer
* Chronic kidney disease
* Heart failure
* Liver failure

About the study

The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.

What is being tested

• Allopurinol (drug)
• Dietary Intervention (other)

Sponsor: Wake Forest University Health Sciences · Participants: 120 · Started: Sep 2, 2020

Contact the study team

• Hossam Shaltout, PhD · Phone: 336-716-1251

Official record on ClinicalTrials.gov — NCT04026776

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.