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AMI Construction in Lower Extremity Residual Limbs

A Novel Approach to Lower Extremity Residual Limb Revision to Augment Volitional Motor Control, Restore Proprioception and Reverse Limb Atrophy

Who can join

Ages 18 to 65 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Between the ages of 18-65
* Has already undergone a standard AKA or BKA procedure
* Suffers from symptoms such as:

  * Intractable pain
  * Deterioration of skin on or around stump
  * Suffering from other sources of discomfort arising from stump
* Intact inherent wound healing
* Adequate communication skills
* High motivation

Exclusion Criteria:

* Inadequate health to undergo operative procedure using standard anesthesia (i.e. cardiopulmonary)
* Individuals with impaired wound healing
* Individuals suffering from extensive peripheral neuropathies
* Active smokers
* Individuals with a history of poor compliance
* Women who are pregnant or plan to become pregnant before surgical intervention

About the study

This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy

What is being tested

• Residual limb revision (procedure)

Sponsor: Brigham and Women's Hospital · Participants: 26 · Started: Feb 24, 2020

Contact the study team

• Matthew J Carty, MD · Phone: 6179834555

Official record on ClinicalTrials.gov — NCT04063592

Locations in the U.S.

Conditions

• Phantom Limb

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.