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Peptide Receptor Radionuclide Therapy (PRRT) for the Treatment of Neuroendocrine Tumors
RecruitingObservational study
Peptide Receptor Radionuclide Therapy (PRRT) for the Treatment of Neuroendocrine
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria:
1. \> 18 years of age
2. Diagnosed with gastroenteropancreatic primary NET and has consented to undergo PRRT per the treating physician. Specifically:
* Will consider other primaries on a case by case basis if dotatate scan (+) and meet all other criteria.
* Metastatic or Locally Advanced AND Inoperable
* Clear disease progression on Octreotide over less than 3 years (RECIST 1.1)
* Presence of disease within 24 weeks as identified by PET/CT scans with Ga-68 DOTATATE reporting the Krenning score for low-grade NET and/or PET/CT scans with FDG for transformation to high-grade NET
* Well differentiated on path - Ki67 \< 20%
* Octreotide positive on pathology (if not documented, acceptable if PET/CT imaging shows lesions with Ga-68 DOTATATE uptakeLabs:
* Cr. \<1.7
* Hgb \>8
* WBC \>2K
* Plt \>75K
* Bili \< 3x normal limit
* No Octreotide within 30 days of administration.
3. Willing and able to comply with the protocol requirements
4. Able to comprehend and sign the Informed Consent Form in English.
Exclusion Criteria:
* Do not meet the Study Inclusion Criteria laid out in section 6.3About the study
The specific aim is of this study is to gain a better understanding of the patient characteristics, treatment responses, survival outcomes, and adverse events associated with PRRT in patients with gastroenteropancreatic primary NETs.
What is being tested
- Peptide Receptor Radionuclide Therapy (procedure)
Sponsor: Methodist Health System · Participants: 50 · Started: Mar 28, 2024
Contact the study team
- Colette N Ndjom, MS · Phone: 214-947-1280
- Jennifer Kirchner · Phone: 214-947-1280
Official record on ClinicalTrials.gov — NCT04090034
Locations in the U.S.
| Texas | Clinical Research Institute at Methodist Health System, Dallas |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.