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Tissue Analysis After Tumor Ablation for Liver Metastases Leading to Immediate Retreatment

Clinical Trial Optimizing Tumor Ablation for Liver Metastases: Rapid Tissue Analysis Allowing for Immediate Retreatment; Metabolic Imaging Biomarker Validation; and Predictive Genetic Signatures

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Diagnosis of liver metastases from various primary tumors
* Confined liver disease or limited extrahepatic disease stable/controlled for at least 4 months (extrahepatic disease amenable to treatment is allowed)
* Lesions of ≤3 cm in maximum diameter
* At least one FDG-avid lesion to be treated\*\*\*
* INR \< 1.5\*
* Platelet count ≥ 50,000

Exclusion Criteria:

* Age \< 18
* Less than 5 mm distance to a structure (GI or biliary tract), that cannot be protected from ablation injury with technical modifications such as hydro or air dissection
* INR \> 1.5 that cannot be corrected with fresh frozen plasma \*\*
* Platelet count of \<50,000 that cannot be corrected with transfusion
* More than 3 tumors in the liver
* More than 5 tumors of extrahepatic disease (including mediastinal nodes and pulmonary nodules, abdominal or other lymph nodes, and bone metastasis)
* Presence of any peritoneal Carcinomatosis

  * For patients on Coumadin, general clinical guidelines for IR ablation will be followed.

    * For patients with no FDG-PET avid tumors aim 2 of the protocol will not be assessed

About the study

This study will see whether collecting and analyzing needle biopsy samples from cancer liver metastases after a tumor ablation procedure will be able to identify cancer cells that are still alive. The results of these biopsies could help determine the next treatment for your cancer, but the biopsies could cause side effects.

What is being tested

• [18-F]- FDG - PET (diagnostic test)
• Tumor ablation (TA) (procedure)
• PET/CT Scan (diagnostic test)

Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 200 · Started: Oct 25, 2019

Contact the study team

• Constantinos Sofocleous, MD, PhD · Phone: 212-639-3379
• Efsevia Vakiani, MD,PhD · Phone: 646-888-3060

Official record on ClinicalTrials.gov — NCT04143516

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.