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RH Genotype Matched RBC Transfusions
RecruitingPhase 1/2
RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell Disease
Who can join
6 Months · All sexes
Full eligibility criteria
Inclusion Criteria: * Subjects age \>6 months * Diagnosis of SCD, all genotypes * Require a period of chronic red cell transfusion therapy * Subject/parental/guardian permission (informed consent) and if appropriate, child assent Exclusion Criteria: * Rare RH genotype that would preclude identification of sufficient RBC units * Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units * Alloimmunized to D antigen * Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols * Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures
About the study
To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
What is being tested
- Red cell units that are genotype matched at the RHD and RHCE loci (biological)
Sponsor: Children's Hospital of Philadelphia · Participants: 35 · Started: Jan 30, 2020
Contact the study team
- Stella Chou, MD · Phone: 215-590-0947
Official record on ClinicalTrials.gov — NCT04156893
Locations in the U.S.
| Pennsylvania | Children's Hospital of Philadelphia, Philadelphia |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.