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Effects of a Specific Substance in Smokers
An MRI Study of Neural Activity Following Exposure to a Specific Substance in Young Cigarette Smokers
Who can join
Ages 21 to 40 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Participants must be 21-40 years old * Right-handed * Fluent in English * Report smoking cigarettes or e-cigarettes 1-27 days in the past month * Report binge drinking based on NIAAA criteria (5 or more drinks per occasion for males, 4 or more drinks per occasion for females) at least 1 time in the past 90 days without adverse incident Exclusion Criteria: * Seeking treatment for substance use (e.g. nicotine or alcohol use) * Moderate or Severe Nicotine Dependence * Current alcohol use disorder * Illicit substance use other than marijuana use in the past year * Marijuana use more than 10 times in the past year * Major neurological or medical illness - Significant head trauma - Current use of medication affecting the central nervous system * MRI contraindications (e.g. irremovable metal on the body or pregnancy)
About the study
Although rates of cigarette use are declining, the proportion of nondaily smokers is rising, particularly among young adults. Among young adults, nondaily smoking is associated with negative health consequences and, for some, may lead to the establishment of life-long smoking patterns. The goal of this project is to understand the behavioral, psychological and neurobiological factors that contribute to cigarette use in nondaily smokers to aid the development of tailored evidence-based interventions.
What is being tested
- Study Agent (drug)
- Placebo (drug)
Sponsor: Oregon Health and Science University · Participants: 60 · Started: Feb 25, 2020
Contact the study team
- Angelica M Morales, PhD · Phone: 503-494-4221
Official record on ClinicalTrials.gov — NCT04281979
Locations in the U.S.
| Oregon | Oregon Health and Science University, Portland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.