Home › Heat Illness › NCT04284397
Identification of Critical Thermal Environments for Aged Adults
RecruitingEarly phase 1Healthy volunteers welcome
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Adults aged 18 and older (those 40+ years of age must be cleared by collaborating physician) * All premenopausal women will be eumenorrheic (by survey) * Asymptomatic and no signs/symptoms of disease according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription Exclusion Criteria: * Medications that affect thermoregulatory or cardiovascular responses to exercise * Any contraindications to low intensity physical activity on the Physical Activity Readiness Questionnaire * Any mobility restrictions that interfere with low intensity physical activity * Pregnant or planning to become pregnant in the next 12 months * Prior diagnosis of cancer, cardiovascular disease, diabetes, or metabolic syndrome * Illegal/recreational drug use * History of Chron's disease, diverticulitis, or similar gastrointestinal disease * Abnormal resting or exercise electrocardiogram (ECG)
About the study
This study evaluates critical environmental limits (temperature and humidity) above which older adults are unable to effectively thermoregulate. Participants will exercise in a series of different environmental conditions to identify combinations of temperature and humidity above which age-related physiological changes cause uncompensable heat stress, resulting in increased risk of heat illness.
What is being tested
- Low dose ASA (drug)
- Control (other)
Sponsor: Penn State University · Participants: 190 · Started: Dec 30, 2020
Contact the study team
- Lacy M Alexander, Ph.D. · Phone: 8148671781
Official record on ClinicalTrials.gov — NCT04284397
Locations in the U.S.
| Pennsylvania | Noll Laboratory, University Park |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.