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TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
Recruiting
TUBectomy With Delayed Oophorectomy as Alternative for Risk-reducing Salpingo-oophorectomy in High Risk Women to Assess the Safety of Prevention: TUBA-WISP II Study.
Who can join
Ages 25 to 50 · Women
Full eligibility criteria
Inclusion Criteria: * Women with a class 5 (definitely pathogenic) BRCA1, BRCA2, RAD51C, RAD51D or BRIP1 germline mutation in one of the participating centers. * Age at inclusion; * BRCA1: 25-40 years * BRCA2: 25-45 years * RAD51C, RAD51D, BRIP1: 25-50 years * Childbearing completed * Presence of at least one fallopian tube * Participants may have a personal history of non-ovarian malignancy * Informed consent must be obtained and documented according to national and local regulatory requirements and the local rules followed in the institution. Exclusion Criteria: * Postmenopausal status (natural menopause or due to treatment) * Wish for second stage RRO within two years after RRS * Legally incapable * Prior bilateral salpingectomy * A personal history of ovarian, fallopian tube or peritoneal cancer * Current diagnosis or treatment for malignant disease
About the study
The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.
What is being tested
- Risk-reducing salpingectomy with delayed oophorectomy (procedure)
- Risk-reducing salpingo-oophorectomy (procedure)
Sponsor: University Medical Center Nijmegen · Participants: 3,000 · Started: Mar 1, 2020
Contact the study team
- Joanne A. de Hullu, MD, PhD · Phone: +31 (0) 24 36 16683
- Karen H. Lu, MD, PhD · Phone: (713) 745-8902
Official record on ClinicalTrials.gov — NCT04294927
Locations in the U.S.
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.