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The Role of Oxytocin in the Second Stage of Labor

Role of Oxytocin in the Second Stage of Labor: a Randomized Controlled Trial (The ROSSoL Trial)

Who can join

All ages · Women · Healthy volunteers welcome

Inclusion Criteria:

* Nulliparous pregnant women \>/= 37 weeks gestation
* Singleton pregnancies
* Admission for induction of labor or spontaneous labor

Exclusion Criteria:

* Multiple gestations
* Multiparous patients
* Patients with major fetal anomalies
* Not on oxytocin at the time of complete cervical dilation
* Patients with fetal head visible at the perineum on diagnosis of complete cervical dilation
* Maternal medical condition that prohibits prolonged second stage

About the study

This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor.

What is being tested

• Continue Oxytocin (drug)
• Discontinue Oxytocin (other)

Sponsor: Washington University School of Medicine · Participants: 400 · Started: Jul 1, 2022

Contact the study team

• Nandini Raghuraman, MD MSCI · Phone: 9186917389

Official record on ClinicalTrials.gov — NCT04303702

Locations in the U.S.

Conditions

• Childbirth Problems

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.