Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
RecruitingObservational study
Who can join
Ages 18 to 50 · All sexes
Full eligibility criteria
Inclusion Criteria: * 18-50 years old * BMI of 25 - 30 kg/m2 * BMI \> 40kg/m2 * Lactate levels in top and lower 25% Exclusion Criteria: * Pregnant women * Mentally disabled * Prisoners * Smokers * Subjects with heart disease * Type 1 and 2 diabetes * Endocrine disease * Hypertension * Musculoskeletal disease * Peripheral occlusion * Hepatic disease * Have had weight fluctuations exceeding + 3% in the previous 12 months * On medications which alter carbohydrate metabolism will not be studied
About the study
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
What is being tested
- Weight loss surgery (procedure)
Sponsor: East Carolina University · Participants: 100 · Started: Mar 3, 2020
Contact the study team
- Terry Jones, PhD · Phone: 2527446249
- Nicholas Broskey, PhD · Phone: 2527374684
Official record on ClinicalTrials.gov — NCT04320264
Locations in the U.S.
| North Carolina | East Carolina University, Greenville |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.