The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy
Who can join
Ages 0 to 39 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Pregnant women less than 16 weeks gestational age * Between the ages of 21-39 years * Pre-pregnancy BMI 28-39 kg/m2 Exclusion Criteria * Pre-gestational diabetes or prediabetes * History of gestational diabetes * History of pre-eclampsia, spontaneous pre-term delivery, or gestational hypertension \<34wks * Tobacco or illicit substance use * Chronic steroid use
About the study
This study plans to learn more about how triglyceride levels in pregnancy affect newborn fat mass. Obesity in pregnancy, in the absence of gestational diabetes, is now the most common cause of large-for-gestational-age infants and increased newborn fat mass. Previous data supports the idea that maternal triglycerides, not glucose, are the strongest predictor of both total newborn fat mass and liver fat. In this study, mothers will monitor triglyceride and glucose levels at specific points in pregnancy using point-of-care meters at home. Two weeks after birth, infants will have total fat measured by air-displacement plethysmography (PEAPOD) and liver fat measures by Magnetic Resonance Spectroscopy (MRS). The central hypothesis is that in obesity, fasting triglycerides and postprandial triglycerides will predict newborn fat mass in a free-living environment.
Sponsor: University of Colorado, Denver · Participants: 140 · Started: Mar 1, 2022
Contact the study team
- Emily Z Dunn, MS, RDN · Phone: 303-724-0320
- Nicole Hirsch, MS · Phone: 303-724-0572
Official record on ClinicalTrials.gov — NCT04394806
Locations in the U.S.
| Colorado | University of Colorado/Anschutz Medical Campus, Aurora |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.