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The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

RecruitingObservational study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Subject Age is \> 18
* Subject with a Head CT that demonstrates an acute, spontaneous, primary, supratentorial ICH of volume \> 20 mL, assessed via standard of care techniques
* Subject Surgery can be initiated within 24 hours of the last known well time or, in patients with wake-up onset, within 24 hours of the time the patient awoke with symptoms.
* Subject has a NIHSS score \> 5
* Subject has a baseline Modified Rankin Scale (mRS) Score ≤ 2
* Subject with a CT Angiography demonstrating no vascular malformation

Exclusion Criteria:

* Subject has an underlying vascular lesion defined as causative source of ICH
* Subject has a profound neurological deficit defined as fixed/dilated pupils or bilateral extensor motor posturing
* Subject has an Infratentorial or brainstem ICH
* Subject has a known life expectancy \< 6 months
* Subject has an uncorrectable coagulopathy
* Subject has a mechanical heart valve
* Subject is pregnant
* Subject participates in another concurrent interventional clinical trial
* Subject who is unable to meet study follow-up requirements

About the study

This registry will study the use of the Aurora® Surgiscope to provide surgical access and visualization in minimally invasive removal of hematoma in the brain. Many methods of hematoma removal are available and will be based on surgeon preference. The impact of patient selection and time to surgery from last known well time will be explored.

What is being tested

Sponsor: Integra LifeSciences Corporation · Participants: 500 · Started: Oct 23, 2020

Contact the study team

Official record on ClinicalTrials.gov — NCT04494295

Locations in the U.S.

CaliforniaProvidence Health, Burbank
FloridaUniversity of Miami, Miami
University of South Florida, Tampa
IllinoisRush University Medical Center, Chicago
MarylandMedStar Health Research Institute, Baltimore (Not yet recruiting)
MissouriUniversity of Missouri, Columbia
Washington University in St. Louis, St Louis
New JerseyJFK university, Edison
New YorkUniversity at Buffalo, Buffalo
Icahn School of Medicine at Mount Sinai, New York
North CarolinaUniversity of North Carolina, Chapel Hill
OhioCleveland Clinic, Cleveland
OklahomaUniversity of Oklahoma, Oklahoma City
PennsylvaniaPennsylvania State University, Hershey
South CarolinaPrisma Health - Upstate, Greenville
TexasUT Health, Houston (Not yet recruiting)
UtahUniversity of Utah, Salt Lake City
WashingtonUniversity of Washington - Harborview, Seattle

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.