Home › Diabetic Eye Problems › NCT04505618

Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

Who can join

Ages 18 to 99 · All sexes · Healthy volunteers welcome

Exclusion Criteria:

* Both subjects with diseases and controls:
* Children (age\<18)
* Pregnant females
* Developmentally delayed subjects
* Subjects unable to provide informed consent
* Inability to cooperate with tests and study instructions
* Images with motion artifact or signal strength \< 7
* History of glaucoma
* History of age-related macular degeneration
* History of any visually significant eye disease
* History of proliferative diabetic retinopathy
* History of any inflammatory disease
* History of heart disease
* History of thyroid disease.
* Additional criteria for controls:
* History of any type of Diabetes Mellitus
* History of any type of Hypertension

About the study

This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.

What is being tested

• Swept-Source (SS) OCT Angiography (device)
• Spectral-Domain (SD) OCT Angiography (device)
• Fundus Imaging (device)
• Axial Length Measurement Device (device)

Sponsor: Johns Hopkins University · Participants: 1,050 · Started: Oct 1, 2019

Contact the study team

• Amir H Kashani, MD, PhD · Phone: 410-502-2789
• Ana C Martinez, MPH · Phone: 410-502-2789

Official record on ClinicalTrials.gov — NCT04505618

Locations in the U.S.

Conditions

• Diabetic Eye Problems
• Essential Hypertension

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.