Home › Bicuspid Aortic Valve Disease › NCT04645862

Prospective 4D CTA of BAV Competence

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* At least 18 years of age
* Documented bicuspid aortic valve identified via clinical imaging (e.g., CT, MRI, or echocardiogram) with minimal calcification at the time of enrollment
* Participant must sign the informed consent form

Exclusion Criteria:

* Pregnancy (determined by point of care urine pregnancy test)
* Renal failure (estimated Glomerular Filtration Rate (eGFR) \< 30), precluding them from receiving intravenous contrast)
* Documentation of previous intravenous contrast allergy (unless they are having a CT with steroid preparation as part of routine clinical care)
* Previous aortic valve replacement

About the study

The study involves annual 4D CTA imaging of the bicuspid aortic valve for a period of 5 years. CTA is often standard of care for BAV patients, but patients in this study will receive a higher radiation dose with a 4D imaging protocol. There may also be patients enrolled in the study who have a 4D CTA for research purposes when a routine CTA is not required for clinical care.

What is being tested

• CT scans (diagnostic test)

Sponsor: University of Pennsylvania · Participants: 60 · Started: Dec 1, 2020

Contact the study team

Official record on ClinicalTrials.gov — NCT04645862

Locations in the U.S.

Conditions

• Bicuspid Aortic Valve Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.