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A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
* Age 18 years or older

Exclusion Criteria:

* Endoscopic removal of all polyps with an indication for removal not possible/feasible
* Gastric or duodenal cancer at baseline endoscopy
* Need for surgery

About the study

The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP)

What is being tested

• Personalized surveillance and intervention protocol (procedure)

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Participants: 1,000 · Started: Nov 24, 2020

Contact the study team

Official record on ClinicalTrials.gov — NCT04677998

Locations in the U.S.

Conditions

• Adenomatous Polyposis Coli

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.