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A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
* Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
* Age 18 years or older

Exclusion Criteria:

* Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
* Cancer at baseline endoscopy
* Need for surgery

About the study

The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.

What is being tested

• Personalized surveillance and intervention protocol (procedure)

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Participants: 1,000 · Started: Nov 24, 2021

Contact the study team

Official record on ClinicalTrials.gov — NCT04678011

Locations in the U.S.

Conditions

• Adenomatous Polyposis Coli

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.