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CHronic Nonbacterial Osteomyelitis International Registry

CHronic Nonbacterial Osteomyelitis International Registry (CHOIR)

Who can join

Up to age 21 · All sexes

Inclusion Criteria:

* \- Age at enrollment is equal to or younger than 21 years of age
* Presence of bone edema on STIR or T2 fat saturation sequence on MRI within 12 weeks of enrollment
* Whole body imaging evaluation (either WB MRI or bone scintigraphy)
* Bone biopsy to exclude infection or malignancy unless bone lesions follow typical distribution or there is IBD, psoriasis, or palmar plantar pustulosis

Exclusion Criteria:

* \- History of or current malignancy
* Current infectious osteomyelitis
* Contraindication to the selected treatment agent

About the study

The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease and the responses of patients to different clinical managements over 10 years.

What is being tested

• Methotrexate (drug)
• Sulfasalazine (drug)
• Leflunomide (drug)
• Pamidronate (drug)
• Zoledronic acid (drug)
• Etanercept (drug)

Sponsor: Seattle Children's Hospital · Participants: 2,000 · Started: Aug 1, 2018

Contact the study team

• Yongdong (Dan) Zhao, MD, PhD · Phone: 206-987-2000

Official record on ClinicalTrials.gov — NCT04725422

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.