Home › Glucose Intolerance › NCT04737200

The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adult male or non-pregnant female volunteers (age 18+)
* Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for \>48 hours
* Able and willing to give consent and comply with study procedures

Exclusion Criteria:

* Blind, deaf or unable to speak English
* Women who are pregnant or nursing
* Contraindications to safe use enteral nutrition, including gastrointestinal obstruction
* Personal history of intestinal malabsorption, gallbladder disease or pancreatitis
* Dietary restrictions precluding enteral feeds
* Renal and liver failure requiring dialysis or Child-Pugh score \> 7
* Severe deficit due to structural or anoxic brain damage
* With skin condition that precludes wearing sensors

About the study

The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.

What is being tested

• Time-of-day of enteral nutrition provision (daytime first) (dietary supplement)
• Time-of-day of enteral nutrition provision (nighttime first) (dietary supplement)

Sponsor: Massachusetts General Hospital · Participants: 30 · Started: Feb 8, 2022

Contact the study team

• Hassan S Dashti, Ph.D., R.D. · Phone: 617-643-7167

Official record on ClinicalTrials.gov — NCT04737200

Locations in the U.S.

Conditions

• Glucose Intolerance

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.