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A Study of Noninvasive Methods to Evaluate Skin and Mucosal Conditions

Noninvasive Assessment of Muco-cutaneous Lesions In Vivo

Who can join

All ages · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* All ages
* Patients with a muco-cutaneous lesion(s) amenable to imaging by non-invasive tools
* Healthy volunteer subjects
* Ability to give informed consent or in the case of pediatric patients, assent and consent from the parent/guardian

Exclusion Criteria:

* Allergy or intolerance to ultrasound gel or mineral oil used for imaging
* Patients who are not able to comply with imaging procedure

About the study

The purpose of this study is to find out whether using noninvasive methods to study the appearance of lesions can improve diagnostic accuracy before a biopsy is required and help guide treatment planning. The database created to store these images is called an Image Repository, and it will be used to support clinical practice, teaching and training, and future research.The High-resolution OCT (Apollo Medical Optics) device ApolloVue® S100 Image System (medical device Class II) can provide both cross-sectional and en-face images with cellular information.

What is being tested

• Dermoscopic imaging (diagnostic test)
• 3-dimensional total body photography (diagnostic test)
• Confocal microscopy (diagnostic test)
• Optical Coherence Tomography imaging (diagnostic test)
• Ultrasound (diagnostic test)
• Hyperspectral imaging (diagnostic test)

Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 5,010 · Started: Feb 2, 2021

Contact the study team

• Manu Jain, MD · Phone: 929-536-3604
• Veronica Rotemberg, MD · Phone: 646-608-2341

Official record on ClinicalTrials.gov — NCT04743362

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.